Search results for " HL60"

showing 4 items of 4 documents

Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway

2022

Oleanolic acid (OA) and Lupeol (LU) belong to the class of natural triterpenes and are endowed with a wide range of biological activities, including cytotoxicity toward several cancer cell lines. In this context, we investigated a set of compounds obtained from the two natural precursors for the cytotoxicity against leukemia HL60 cells and the multidrug-resistant (MDR) variant HL60R. Six new semi-synthetic triterpenes have been synthetized, fully characterized, and were investigated together with other triterpenes compounds for their pharmacological mechanism of action. The interaction of the more cytotoxic compounds with the nuclear factor kappa B (NF-κB) pathway has been also evalua…

CatalysisCell LineInorganic ChemistryNeoplasmsHumansantitumor activityNF-kBPhysical and Theoretical ChemistryMolecular BiologySpectroscopyLeukemiaHL60ROrganic ChemistryNF-kappa BLupeolOleanolic acidSettore CHIM/06 - Chimica OrganicaGeneral MedicineSettore CHIM/08 - Chimica FarmaceuticaTriterpenesComputer Science ApplicationsOleanolic acid; Lupeol; HL60; HL60R; antitumor activity; NF-κB; dockingHL60dockingSettore BIO/14 - FarmacologiaPentacyclic TriterpenesInternational Journal of Molecular Sciences
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Cytotoxic effects of polyphenols from waste-water of extra virgin olive oil on human HL60 and K562 cell lines.

2009

Polyphenols HL60 K562 apoptosisSettore BIO/14 - FarmacologiaSettore BIO/09 - Fisiologia
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Effects of extra virgin olive oil phenols on HL60 cell lines sensitve and resistant to anthracycline

2007

Settore BIO/14 - Farmacologiaphenols extra virgin oliv oil HL60
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Cytotoxic effects of a crude extract of extra virgin olive oil on human HL60 cell lines sensitive and resistant with MDR phenotype

2008

drug resistance HL60 Olive oil
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